Domino Causality sets the guiding principles in the search for innovative drugs. We only can improve productivity by constant attention to the entire line of causality, of the domino chain. Merely optimizing or improving any single link is not helpful.

Dr. Moriarity, a metaphysician, sets up fifty numbered dominoes standing in a straight line with their dots facing the same way on a table in a room, but puts a blind in front of the dominoes so that only numbers one and fifty are visible. You enter the room, and observe that domino number one and domino number fifty are lying flat with their ...